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+--- Thread: Diisononyl phthalate (/Thread-Diisononyl-phthalate)
Diisononyl phthalate - Jessica - 03-03-2018
General Description:
Synonyms: 1,2-Benzenedicarboxylic acid, diisononyl ester; DINP
OSHA IMIS Code Number: D908
Chemical Abstracts Service (CAS) Registry Number: 28553-12-0
NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: www.cdc.gov/niosh-rtecs/cz3abf10.html
Chemical Description and Physical Properties:
oily viscous liquid
molecular weight: 418.68
vapor pressure: <0.01 @ 20°C Pa
molecular formula: C26H42O4
boiling point: 244-252°C
melting point: -43°C
flash point: 221°C closed cup
Health Factors
Potential Symptoms: No clinical reports of symptoms were found
Health Effects: Unknown in humans (no studies found). In animals given high oral doses: liver tumors, kidney lesions and tumors (male rats only); effects on fetal development (rats).
Affected Organs: In rodents: liver, kidneys
Notes:
- OSHA does not have a PEL for diisononyl phthalate (DINP).
- The major metabolites of DINP found in the urine of people with no known occupational exposure to DINP are mono-(hydroxyisononyl) phthalate and mono-(carboxyisooctyl) phthalate.
- Another major urinary metabolite of DINP identified in a volunteer given [2H]-labeled DINP (1.27 mg/kg, oral) was mono-(oxo-isononyl) phthalate. The elimination half-lives were estimated to be approximately 12 hours for the hydroxy and oxo metabolites and about 18 hours for the carboxy metabolite.
- Adverse effects on liver and kidneys in rodents do not occur in monkeys and are thought to not pose a health hazard for these organs in humans.
- International Chemical Safety Cards (WHO/IPCS/ILO): www.cdc.gov/niosh/ipcsneng/neng0831.html.
- National Toxicology Program: www.ncbi.nlm.nih.gov/pubmed/15995726. NTP CERHR MON. (2): i-III90, 2003.
- Caldwell, D.J., Eldridge, S.R., Lington, A.W. and McKee, R.H.: Retrospective evaluation of alpha 2u-globulin accumulation in male rat kidneys following high doses of diisononyl phthalate. Toxicol. Sci. 51(1): 153-160, 1999.
- Gray, L.E., Jr., Ostby, J., Furr, J., Price, M., Veeramachaneni, D.N.R. and Parks, L.: Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol. Sci. 58(2): 350-365, 2000.
- Kaufmann, W., Deckardt, K., McKee, R.H., Butala, J.H. and Bahnemann, R.: Tumor induction in mouse liver: di-isononyl phthalate acts via peroxisome proliferation. Regul. Toxicol. Pharmacol. 36(2): 175-183, 2002.
- Koch, H.M. and Angerer, J.: Di-iso-nonylphthalate (DINP) metabolites in human urine after a single oral dose of deuterium-labelled DINP. Int. J. Hyg. Environ. Health 210(1): 9-19, 2007.
- Pugh, G., Jr., et al.: Effects of di-isononyl phthalate, di-2-ethylhexyl phthalate, and clofibrate in cynomolgus monkeys. Toxicol. Sci. 56(1): 181-188, 2000.
- Silva, M.J., Reidy, J.A., Preau, J.L., Needham, L.L. and Calafat, A.M.: Oxidative metabolites of diisononyl phthalate as biomarkers for human exposure assessment. Environ. Health Perspect. 114(8): 1158-1161, 2006.