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Diisononyl phthalate - Printable Version

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Diisononyl phthalate - Jessica - 03-03-2018

General Description:

Synonyms: 1,2-Benzenedicarboxylic acid, diisononyl ester; DINP 

OSHA IMIS Code Number: D908 

Chemical Abstracts Service (CAS) Registry Number: 28553-12-0 

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: 

Chemical Description and Physical Properties:

oily viscous liquid
molecular weight: 418.68
vapor pressure: <0.01 @ 20°C Pa 
molecular formula: C26H42O4
boiling point: 244-252°C
melting point: -43°C
flash point: 221°C closed cup

Health Factors
Potential Symptoms: No clinical reports of symptoms were found 

Health Effects: Unknown in humans (no studies found). In animals given high oral doses: liver tumors, kidney lesions and tumors (male rats only); effects on fetal development (rats). 

Affected Organs: In rodents: liver, kidneys 


  1. OSHA does not have a PEL for diisononyl phthalate (DINP).
  2. The major metabolites of DINP found in the urine of people with no known occupational exposure to DINP are mono-(hydroxyisononyl) phthalate and mono-(carboxyisooctyl) phthalate.
  3. Another major urinary metabolite of DINP identified in a volunteer given [2H]-labeled DINP (1.27 mg/kg, oral) was mono-(oxo-isononyl) phthalate. The elimination half-lives were estimated to be approximately 12 hours for the hydroxy and oxo metabolites and about 18 hours for the carboxy metabolite.
  4. Adverse effects on liver and kidneys in rodents do not occur in monkeys and are thought to not pose a health hazard for these organs in humans.
Literature Basis:
  • International Chemical Safety Cards (WHO/IPCS/ILO):
  • National Toxicology Program: NTP CERHR MON. (2): i-III90, 2003.
  • Caldwell, D.J., Eldridge, S.R., Lington, A.W. and McKee, R.H.: Retrospective evaluation of alpha 2u-globulin accumulation in male rat kidneys following high doses of diisononyl phthalate. Toxicol. Sci. 51(1): 153-160, 1999.
  • Gray, L.E., Jr., Ostby, J., Furr, J., Price, M., Veeramachaneni, D.N.R. and Parks, L.: Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat. Toxicol. Sci. 58(2): 350-365, 2000.
  • Kaufmann, W., Deckardt, K., McKee, R.H., Butala, J.H. and Bahnemann, R.: Tumor induction in mouse liver: di-isononyl phthalate acts via peroxisome proliferation. Regul. Toxicol. Pharmacol. 36(2): 175-183, 2002.
  • Koch, H.M. and Angerer, J.: Di-iso-nonylphthalate (DINP) metabolites in human urine after a single oral dose of deuterium-labelled DINP. Int. J. Hyg. Environ. Health 210(1): 9-19, 2007.
  • Pugh, G., Jr., et al.: Effects of di-isononyl phthalate, di-2-ethylhexyl phthalate, and clofibrate in cynomolgus monkeys. Toxicol. Sci. 56(1): 181-188, 2000.
  • Silva, M.J., Reidy, J.A., Preau, J.L., Needham, L.L. and Calafat, A.M.: Oxidative metabolites of diisononyl phthalate as biomarkers for human exposure assessment. Environ. Health Perspect. 114(8): 1158-1161, 2006.