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Jessica · 03-03-2018, 12:04 PM

General Description:

Synonyms: Acetic acid dimethylamide; Dimethylacetamide; N,N-Dimethyl acetamide; DMAC

OSHA IMIS Code Number: 0927

Chemical Abstracts Service (CAS) Registry Number: 127-19-5

NIOSH Registry of Toxic Effects of Chemical Substances (RTECS) Identification Number: www.cdc.gov/niosh-rtecs/AB757E20.html

NIOSH Pocket Guide to Chemical Hazards, www.cdc.gov/niosh/npg/npgd0218.html: chemical description, physical properties, potentially hazardous incompatibilities, and more.

Exposure Limits
OSHA Permissible Exposure Limit (PEL):
General Industry: www.osha.gov/pls/oshaweb/owadisp.show_document?p_table=STANDARDS&p_id=9992&p_text_version=FALSE -- 10 ppm, 35 mg/m3 TWA; Skin

Construction Industry: www.osha.gov/pls/oshaweb/owadisp.show_document?p_table=STANDARDS&p_id=10629 -- 10 ppm, 35 mg/m3 TWA; Skin

Maritime: www.osha.gov/pls/oshaweb/owadisp.show_document?p_table=STANDARDS&p_id=10286&p_text_version=FALSE -- 10 ppm, 35 mg/m3 TWA; Skin
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 10 ppm, 36 mg/m3 TWA; Skin; Appendix A4 - Not Classifiable as a Human Carcinogen; BEI (TLV listed under N,N-Dimethylacetamide)

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL):10 ppm, 35 mg/m3 TWA; Skin
Health Factors
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): www.cdc.gov/niosh/idlh/127195.html

Potential Symptoms: Irritation of skin; headache, nausea, vomiting; jaundice, liver damage; depression, drowsiness, hallucinations, delusions; INGES. ACUTE: Abdominal cramps, diarrhea; SKIN ABS

Health Effects: Cumulative liver damage (HE3); Suspect teratogen (HE5); CNS effects (HE7); Irritation-Eyes, Skin---Mild (HE16)

Affected Organs: Skin, liver, CNS

Notes:

Explosive vapor/air mixtures of dimethyl acetamide may be formed above 70°C.
Developmental toxicity studies of dimethyl acetamide by inhalation exposure in rats reported a NOAEL of 100 ppm for both maternal toxicity (hepatocellular swelling) and fetal toxicity (fused bones and life-threatening cardiovascular malformations) that were observed at higher concentrations.
Dermal absorption of dimethylacetamide vapor was extensive in 12 volunteers exposed (90% naked) in a chamber to 6.1 ppm for 4 hours, ranging from 13% to 73% of the total absorbed dose (mean, 40%).
N-methylacetamide in urine (adjusted for creatinine) is measured at the end of a shift for biomonitoring N,N-dimethylacetamide exposure. Mean biological half-lives after dermal and respiratory exposure were estimated to be 9.0 and 5.6 hours, respectively.
The incidence rate ratio for liver injury among elastane fiber employees exposed to dimethylacetamide was reported to be 9.6 for those with urinary N-methylacetamide levels >20 mg/g creatinine compared with those having levels <20 mg/g creatinine during exposure monitoring.
Dermal absorption of dimethylacetamide is decreased by showering and changing clothing at the end of a work shift.

Date Last Revised: 04/23/2007

Literature Basis:

NIOSH Pocket Guide to Chemical Hazards: www.cdc.gov/niosh/npg/npgd0218.html.
International Chemical Safety Cards (WHO/IPCS/ILO): www.cdc.gov/niosh/ipcsneng/neng0259.html.
Lee, C.-Y., Jung, S.-J., Kim, S.-A., Park, K.-S. and Ha, B.-G. Incidence of dimethylacetamide induced hepatic injury among new employees in a cohort of elastane fibre workers. Occup. Environ. Med. 63(10): 688-693, 2006.
Nimiyama, T., et al. Dermal absorption of N,N-dimethylacetamide in human volunteers. Int. Arch. Occup. Environ. Health 73(2): 121-126, 2000.
Okuda, H., et al. Developmental toxicity induced by inhalation exposure of pregnant rats to N,N-dimethylacetamide. J. Occup. Health 48(3): 154-160, 2006.
Perbellini, L., Princivalle, A., Caivano, M. and Montagnani, R. Biological monitoring of occupational exposure to N,N-dimethylacetamide with identification of a new metabolite. Occup. Environ. Med. 60(1): 746-751.
Pohanish, R.P. (editor) N,N-Dimethylacetamide. In Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 905-907.

Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:

sampling media: Silica Gel Tube (150/75 mg sections, 20/40 mesh)
analytical solvent: Methanol
maximum volume: 80 Liters
maximum flow rate: 1.0 L/min )
current analytical method: Gas Chromatography; GC/FID
method reference: NIOSH Analytical Method (www.cdc.gov/niosh/docs/2003-154/pdfs/2004.pdf) [27 KB PDF, 5 pages]
method classification: Fully Validated